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INFORMATION there for you to learn from. It's the type
of information that not only saved my life...It also has
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Continued From 5/26/14
By Dr. Mercola
The Potential Role of Protein in Cancer Formation
Glutamine--one of the most common amino acids found in
proteins is another interesting aspect of cancer that Dr.
Seyfried is still investigating. In his opinion, most
oncologists who do cancer metabolism recognize that sugar
(both glucose and fructose) is the prime fuel for driving
tumor growth. However, mounting research also indicates that
glucose and glutamine together act powerfully and
synergistically on the growth of tumor cells.
"These two fuels work together in concert to provide a
continual growth," he says.
One of my early mentors was Dr. Ron Rosedale. He taught
me, about 20 years ago, about the importance of insulin
control and then, more recently, about the importance of
reducing protein intake, for this very reason. Most Americans
likely eat far more protein than they really need, and this
excess could be a factor in cancer. The Paleo approach makes
sense on many levels, especially with regards to intermittent
fasting and lowering your glucose levels. The Paleo approach
is very clear about reducing grains and any food that raises
your blood sugar. But there are, of course, two other
macronutrients left: fat and protein.
Many Paleo followers are overly concerned about getting
high amounts of protein, which could increase your glutamine
and branched chained amino acid levels, which in turn tend to
activate mTOR. In some, that could be problematic. According
to Dr. Rosedale's research, the pathway known as the
mammalian target of rapamycin (mTOR), is controlled by
lowering your protein intake. This pathway may be another
metabolic pathway that helps control and prevent cancer
Calorie Restriction Is a Key Part of the Equation
Dr. Seyfried, however, is more cautious in his evaluation
of mTOR and reducing protein for cancer prevention. In his
view, the most important aspect of cancer prevention and
treatment is the intermittent fasting, or overall calorie
restriction, which includes eating less of everything,
period. But while calories from carbohydrates should be
virtually eliminated, calories from protein just need to be
reduced, while most need to increase their intake of
healthful fats to get a more ideal ratio of fat to protein.
As far as the specific types of fats recommended, Dr.
Seyfried uses medium-chain triglycerides, i.e. coconut oil,
butter, macadamia nuts, and other types of saturated fats,
which is what I've long recommended as well. "The saturated
fats are converted to ketones much more readily than
polyunsaturated fats," he explains.
So, keep in mind that for cancer prevention and
treatment, the actual calorie restriction is an important
part of the equation:
"We did some studies on this with our model of glioma...
The mTOR in our model was not dramatically changed by these
metabolic therapies. But I know others have reported it, and
this could be an important component for certain other kinds
of cancers. But my limited work with this did not demonstrate
this to be a major issue, at least in the glioma model that we
looked at. We showed that you could give animals a high-fat,
low-protein diet, as much as they want (zero carbs in this diet),
and their blood glucose was just as high or higher than the mice
that were eating the protein-carb diet.
It was more or less related to the total consumption
of calories. Most calories boil down to glucose. Proteins
will be metabolized to glucose. Carbs are metabolized to
glucose; fats are not... We don't get any therapeutic benefit
either in epilepsy or cancer when we allow the animals or
people to eat as much of these high-fat diets as they want.
We get no therapeutic benefit.
Therapeutic benefit comes from the restriction of the
calories in the diet. The ketogenic diet or a low-carb, low-
protein diet is simply a way to take the sting out of a
therapeutic fast. Because as long as the glucose and ketones
can get into the metabolic range (and you can do it with
eating small amounts of a high-fat diet rather than
therapeutic fasting), then that just makes people feel a
little better about how they're doing this rather than
feeling that I'm starving to death."
Hyperbaric Oxygen Therapy
I recently interviewed Dr. D'Agostino who is another
cancer as a metabolic disease researcher. He published a
recent paper that shows a phenomenal synergy with a
ketogenic diet and the use of hyperbaric oxygen for cancers
that have metastasized. These types of cancers are
notoriously difficult to treat. I would strongly encourage
anyone struggling with this challenge to consider this type
From my perspective, it's nothing short of medical
malpractice and negligence to fail to integrate this type of
dietary strategy into a patient's cancer treatment plan
(along with optimizing vitamin D). A ketogenic diet along
with intermittent fasting can be easily integrated into
whatever cancer treatment plan you decide to follow.
Personally, I believe it's absolutely crucial, no matter what
type of cancer you're trying to address.
That said, remember that a ketogenic diet, in which you
replace carbs with low to moderate amounts of protein and
high amounts of beneficial fat, like avocado, coconut oil,
butter, olive oil and macadamia nuts is recommended for
everyone, whether you have cancer or not. It's a diet that
will help optimize your weight and health overall, as eating
this way will help you convert from carb burning mode, to fat
To get more specifics about using a ketogenic diet and
calorie restriction for the treatment of cancer, I highly
recommend picking up Dr. Seyfried's book, Cancer as a
Metabolic Disease. You can also review his papers, which
outline the guidelines and treatment strategies for cancer
patients. If you're a cancer patient, I'd recommend printing
them out for your oncologist.
Thank You Dr. Mercola
God Bless Everyone & God Bless The United States of America.
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