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By Dr. Mercola
Could a ketogenic diet eventually be a "standard of care"
drug-free treatment for cancer? Personally, I believe it's
absolutely crucial, for whatever type of cancer you're trying
to address, and hopefully some day it will be adopted as a
first line of treatment.
A ketogenic diet calls for eliminating all but non-
starchy vegetable carbohydrates, and replacing them with
healthy fats and high-quality protein.
The premise is that since cancer cells need glucose to
thrive, and carbohydrates turn into glucose in your body,
then lowering the glucose level in your blood though carb
and protein restriction literally starves the cancer cells into
oblivion. Additionally, low protein intake tends to minimize
the mTOR pathway that accelerates cell proliferation.
This type of diet, in which you restrict all but non-starchy
vegetable carbs and replace them with low to moderate
amounts of high-quality protein and high amounts of
beneficial fat, is what I recommend for everyone, whether you
have cancer or not. It's a diet that will help optimize your
weight and all chronic degenerative disease. Eating this way
will help you convert from carb burning mode to fat burning.
Dr. Thomas Seyfried is one of the leading pioneer
academic researchers in promoting how to treat cancer
nutritionally. He's been teaching neurogenetics and
neurochemistry as it relates to cancer treatment at Yale
University and Boston College for the past 25 years.
He's written over 150 peer-reviewed scientific articles
and book chapters, and has also published a book, Cancer as a
Metabolic Disease: On the Origin, Management, and Prevention
of Cancer.
Ketogenic Diet Accepted as First Line Approach for Epilepsy;
Is Cancer Next?
The ketogenic diet has actually been used for managing
seizures in children for quite some time. While Dr. Seyfried
and his team worked on brain cancer and epilepsy in mice,
one of his students suggested investigating whether or not a
ketogenic diet might also be effective against tumors.
So, in the late '90s, they began dovetailing their work
on ketogenic diets and epilepsy and cancer together,
eventually bringing them to a better understanding of how
changing your whole-body metabolic state can be effective in
targeting and eliminating tumor cells.
Interestingly, clinical medicine has recognized the
ketogenic diet as a valuable option in the treatment of
epilepsy since the late 90's.
"I served as the organizer for the Ketogenic Diet
Special Interest Group at the American Epilepsy Society,
" Dr.Seyfried says.
"We initially started as a small focus group with the
folks from Johns Hopkins Medical School, where the diet has
had its greatest use and impact. And then we started to grow
and substantially increase interest mainly through the
efforts of Jim Abrahams.
Jim started the Charlie Foundation for his son Charlie,
who went through a near-death experience from seizures
and was rescued using ketogenic diets. His colleague, Meryl
Streep, the famous movie actress, became very involved in this.
Now the ketogenic diet is receiving considerable attention
in the epilepsy community as a first line of approach. Although
this is still not widely accepted, I have to admit that the ketogenic
diet is now recognized as an important component for the
management of refractory seizures in children."
According to Dr. Seyfried, the mechanism by which the
ketogenic diet manages seizures is not nearly as clear as the
way the ketogenic diet manages cancer. This is ironic
considering that it's barely known, let alone applied, within
oncology circles, while it's already a first line of
treatment for epilepsy. In the case of cancer, it's well-
established that it's the glucose reduction that kills the
cancer cells.
Cancer Is a Mitochondrial Metabolic Disease
Dr. Seyfried has developed a process called metabolic
control analysis, which essentially analyzes the metabolic
flux through different pathways that occurs when you
transition your body from one major fuel source to another
major fuel source, to maintain energy homeostasis in your
body. Many believe or are under the impression that cancer
is primarily a genetic disease, but Dr. Seyfried dispels such
notions.
"We're not going to make major advances in the
management of cancer until it becomes recognized as a
metabolic disease. But in order to do that, you have to
present a massive counterargument against the gene theory
of cancer," he says.
"One of the key issues here is that if you transplant
the nucleus of a cancer cell into a normal cell, you don't
get cancer cells. You can actually get normal tissues and
sometimes a whole normal organism from the nucleus of a
cancer cell. Now, if the tumors are being driven by driver
genes all these kinds of mutations and things that we hear
about how is it possible that all of this is changed when you
place this cancer nucleus into the cytoplasm of a cell with
normal mitochondria?
The gene theory cannot address this. It clearly argues
strongly against the concept that genes are driving this
process. Actually, a very few people inherit genes that
predispose them to cancer. Most people inherit genes that
prevent cancer. And those few genes that are inherited the
germ line like the BRCA1 mutations, B53, and a few other
veryrare cancers these inherited mutations appear to disrupt
the function of the mitochondria."
According to Dr. Seyfried, the mitochondria the main
power generators in your cells are the central point in the
origin of most cancers. Your mitochondria can be damaged
not only by inherited mutations, thereby increasing your risk
for a particular type of cancer, such as the BRCA1 and BRCA2
mutations that increase your risk of breast and ovarian cancer.
They can also be damaged by environmental factors, such as
toxins and radiation, both ionizing and non-ionizing.
Over time, damage to your mitochondria can lead to dysfunction
and tumor formation.
"It's ultimately a disease of the mitochondrial
energy metabolism, which is the origin of the disease," Dr.
Seyfried says." Once the mitochondria become dysfunctional or
insufficient in ability, mutations will occur. The drugs that
have been developed based on the genome projects have been
largely ineffective in providing long-term care and are
associated with toxic effects. As long as the field continues
to focus on that part of the disease, which is a downstream
epiphenomenon, there will be no major advances in the field
simply because that's not the relevant aspect of the disease."
Sugar Is the Primary Fuel for Most Cancers
Controlling your blood-glucose leptin and insulin levels
through diet, exercise and emotional stress relief can be one
of the most crucial components to a cancer recovery program.
These factors are also crucial in order to prevent cancer in
the first place.In 1931, the Nobel Prize was awarded to
German researcher Dr. Otto Warburg, who discovered that
cancer cells have a fundamentally different energy metabolism
compared to healthy cells, and that malignant tumors tend to
feed on sugar. More recently, researchers discovered that
while cancer cells feed on both glucose and fructose,
pancreatic tumor cells use fructose specifically to divide
and proliferate.
Dr. Seyfried's work confirms that sugar is the primary
fuel for cancer, and that by restricting sugar and providing
an alternate fuel, namely fat, you can dramatically reduce
the rate of growth of cancer. He explains:
"When we're dealing with glucose and cancer management,
we know from a large number of studies that if respiration of
the tumor is ineffective, in order to survive, the cells must
use an alternative source of energy, which is fermentation.
We know that glucose is the primary fuel for fermentation.
Fermentation becomes a primary energy-generating process
in the tumor cell. By targeting the fuel for that process, we
then have the capability of potentially managing the disease."
The strategy Dr. Seyfried suggests is a low-carb, low to
moderate protein, high-fat diet, which will effectively lower
your blood sugar. This is an easily measurable parameter that
you can check using a diabetic blood glucose meter. This type
of diet, called a ketogenic diet, will also elevate ketone
bodies, as fat is metabolized to ketones that your body can
burn in the absence of food. When combined with calorie
restriction, the end result will put your body in a metabolic
state that is inhospitable to cancer cells.
"Ketones is a fat breakdown product that can replace
glucose as a major fuel for many of the organs and especially
our brain," he says.
Tumor cells, however, cannot use ketone bodies because of
their respiratory insufficiency. So the ketogenic diet represents
an elegant, non-toxic way to target and marginalize tumor cells.
It also allows you to dramatically lower your glucose levels, as
the ketones will protect your body against any hypoglycemia
that might otherwise be induced by carb restriction.
All of the newer cells in your body will be transitioned
to these effective ketones, thereby preventing them from
damage from hypoglycemia. At the same time, the tumor cells
are now marginalized and under tremendous metabolic stress.
It's a whole body therapy you need to bring the whole body
into this metabolic state," he explains.
"We like to call it a new state of metabolic homeostasis:
a state where ketones have reached the steady state level in
your blood and glucose has reached a steady lower level in
your blood... If it's done right and implemented right, it has
powerful therapeutic benefits on the majority of people
who suffer from various kinds of cancers. Because all cancers
have primarily the same metabolic defect."
Thank You Dr. Mercola
Continued 5/26/14
God Bless Everyone & God Bless The United States of America.
Larry Nelson
42 S. Sherwood Dr.
Belton, Tx. 76513
cancercurehere@gmail.com
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