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By Dr. Mercola
Continued From 3/3/14
Dr. Seyfried has developed a process called metabolic control
analysis, hich essentially analyzes the metabolic flux through
different pathways that occurs when you transition your body from
one major fuel source to another major fuel source, to maintain
energy homeostasis in your body. Many believe or are under the
impression that cancer is primarily a genetic disease, but Dr.
Seyfried dispels such notions.
We’re not going to make major advances in the management
of cancer until it becomes recognized as a metabolic disease.
But in order to do that, you have to present a massive
counterargument against the gene theory of cancer, he says.
One of the key issues here is that if you transplant
the nucleus of a cancer cell into a normal cell, you don’t get
cancer cells. You can actually get normal tissues and sometimes
a whole normal organism from the nucleus of a cancer cell. Now,
if the tumors are being driven by driver genes all these kinds
of mutations and things that we hear about how is it possible
that all of this is changed when you place this cancer nucleus
into the cytoplasm of a cell with normal mitochondria?
The gene theory cannot address this. It clearly argues
strongly against the concept that genes are driving this
process. Actually, a very few people inherit genes that
predispose them to cancer. Most people inherit genes that
prevent cancer. And those few genes that are inherited the germ line
like the BRCA1 mutations, B53, and a few other very rare cancers
these inherited mutations appear to disrupt the function of the
According to Dr. Seyfried, the mitochondria—the main power
generators in your cells—are the central point in the origin
of most cancers. Your mitochondria can be damaged not only by
inherited mutations, thereby increasing your risk for a
particular type of cancer, such as the BRCA1 and BRCA2 mutations
that increase your risk of breast and ovarian cancer. They can
also be damaged by environmental factors, such as toxins and
radiation, both ionizing and non-ionizing. Over time, damage
to your mitochondria can lead to dysfunction and tumor formation.
It’s ultimately a disease of the mitochondrial energy
metabolism, which is the origin of the disease, Dr. Seyfried
says. Once the mitochondria become dysfunctional or insufficient
in ability, mutations will occur. The drugs that have been
developed based on the genome projects have been largely
ineffective in providing long-term care and are associated with
toxic effects. As long as the field continues to focus on that
part of the disease, which is a downstream epiphenomenon, there
will be no major advances in the field simply because that’s not
the relevant aspect of the disease.
Sugar Is the Primary Fuel for Most Cancers
Controlling your blood-glucose leptin and insulin levels
through diet, exercise and emotional stress relief can be one
of the most crucial components to a cancer recovery program.
These factors are also crucial in order to prevent cancer in
the first place.In 1931, the Nobel Prize was awarded to German
researcher Dr. Otto Warburg, who discovered that cancer cells
have a fundamentally different energy metabolism compared to
healthy cells, and that malignant tumors tend to feed on sugar.
More recently, researchers discovered that while cancer cells
feed on both glucose and fructose, pancreatic tumor cells use
fructose specifically to divide and proliferate.
Dr. Seyfried’s work confirms that sugar is the primary fuel
for cancer, and that by restricting sugar and providing an
alternate fuel, namely fat, you can dramatically reduce the
rate of growth of cancer.
When we’re dealing with glucose and [cancer] management,
we know from a large number of studies that if respiration of
the tumor is neffective, in order to survive, the cells must use
an alternative source of energy, which is fermentation. We know
that glucose is the primary fuel for fermentation. Fermentation
becomes a primary energy-generating process in the tumor cell.
By targeting the fuel for that process, we then have the
capability of potentially managing the disease.
The strategy Dr. Seyfried suggests is a low-carb, low to
moderate protein, high-fat diet, which will effectively lower
your blood sugar. This is an easily measurable parameter that
you can check using a diabetic blood glucose meter. This type
of diet, called a ketogenic diet, will also elevate ketone
bodies, as fat is metabolized to ketones that your body can
burn in the absence of food. When combined with calorie
restriction, the end result will put your body in a metabolic
state that is inhospitable to cancer cells.
Ketones is a fat breakdown product that can replace
glucose as a major fuel for many of the organs and especially
our brain, he says.
Tumor cells, however, cannot use ketone bodies because of
their respiratory insufficiency. So the ketogenic diet represents
an elegant, non-toxic way to target and marginalize tumor cells.
It also allows you to dramatically lower your glucose levels,
as the ketones will protect your body against any hypoglycemia
that might otherwise be induced by carb restriction.
All of the newer cells in your body will be transitioned
to these effective ketones, thereby preventing them from damage
from hypoglycemia. At the same time, the tumor cells are now
marginalized and under tremendous metabolic stress. It’s a whole
body therapy you need to bring the whole body into this metabolic
state, he explains.
We like to call it a new state of metabolic homeostasis:
a state where ketones have reached the steady state level in
your blood and glucose has reached a steady lower level in your
blood...If it’s done right and implemented right, it has powerful
therapeutic benefits on the majority of people who suffer from
various kinds of cancers. Because all cancers have primarily
the same metabolic defect.
For Cancer Protection, Reverse Your Glucose to Ketone Ratios
Dr. Seyfrieduses ketones and glucose as the measures of
this new metabolic state. The parameters associated with an
ideal state are ketone levels equal to or higher than the
glucose level in your blood.
There’s a high ratio of glucose to ketones. But in a
fasted or therapeutic state, this ratio is actually reversed.
Ketones can actually become higher than glucose, he says. What
they can do is they can get their blood sugars down to 2.5 to
3 millimolar [equivalent to about 55-65 mg/dl], and then their
ketones to up to 3 or 4 millimolar, where the ratio is now
reversed. It’s this state that now brings the body into this
You can easily check your glucose levels at home, you’d
need to work with a doctor to measure ketone levels in your
blood. Generally speaking, a fasting glucose under 100 mg/dl
suggests that you're not insulin resistant, while a level
between 100-125 suggests you're either mildly insulin resistant
or pre-diabetic. Here, Dr. Seyfried recommends getting your
glucose down to a steady level of about 55-65 mg/dl, which is
about HALF of what’s conventionally considered good or normal.
Blood ketones can be easily measured using the Medisense
Precision Xtra blood glucose and ketone monitor from Abbot
Laboratory. As many pharmacies might not stock the meter (bar
code #, 93815 80347), it might be necessary to call Abbott directly
(1-800-527 3339) to obtain the meter. According to Dr. Seyfried,
the Precision Xtra seems the most accurate of all the ones
It is important to mention, however, that the blood ketone
strips are more expensive than the blood glucose strips. Dr.
Seyfried therefore recommends measuring your blood ketones every
few days rather than 3x/day for blood glucose. Although urine
ketone measurement is a cheap way to assess ketones, urine ketone
levels are not always indicative of blood ketone levels. It is
best if you can measure ketones from both blood and urine.
I work with nutritionists and physicians, Dr. Seyfried
says. The problem with cancer patients is that many of the
practitioners are unfamiliar with this whole approach, so there’s
this tremendous gap.
We have knowledge of how to do this. We have patients willing
to do it. But we lack professionals that are trained or even
understand the concepts of how to implement these kinds of
All of the guidelines are included in Dr. Seyfried’s book,
Cancer as Metabolic Disease, which is available on Amazon. He’s
also published a couple of papers 1,2 that outline the
guidelines and treatment strategies for cancer patients. One
caveat to consider is your use of medications, as you need to
know what the adverse effects might be if you use a medication
at a particular dosage along with this kind of metabolic therapy.
Thank You Dr. Mercola
God Bless Everyone & God Bless The United States of America.
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